Research progress of the Elongator complex in plant

Authors

  • Ji XIANGZHUO Gansu Agricultural University, College of Agronomy, Lanzhou 730070; Gansu Agricultural University, Gansu Provincial Key Lab of Arid Land Crop Science, Lanzhou 730070; Gansu Agricultural University, Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Lanzhou 730070 (CN)
  • Zhuang ZELONG Gansu Agricultural University, College of Agronomy, Lanzhou 730070; Gansu Agricultural University, Gansu Provincial Key Lab of Arid Land Crop Science, Lanzhou 730070; Gansu Agricultural University, Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Lanzhou 730070 (CN)
  • Wang YINXIA Gansu Agricultural University, College of Agronomy, Lanzhou 730070; Gansu Agricultural University, Gansu Provincial Key Lab of Arid Land Crop Science, Lanzhou 730070; Gansu Agricultural University, Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Lanzhou 730070 (CN)
  • Zhang YUNFANG Gansu Agricultural University, College of Agronomy, Lanzhou 730070; Gansu Agricultural University, Gansu Provincial Key Lab of Arid Land Crop Science, Lanzhou 730070; Gansu Agricultural University, Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Lanzhou 730070 (CN)
  • Peng YUNLING Gansu Agricultural University, College of Agronomy, Lanzhou 730070; Gansu Agricultural University, Gansu Provincial Key Lab of Arid Land Crop Science, Lanzhou 730070; Gansu Agricultural University, Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Lanzhou 730070 (CN)

DOI:

https://doi.org/10.15835/nbha51113058

Keywords:

DNA methylation, Elongator complex, histone acetylation, RNA polymerase II, tRNA modification

Abstract

The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six subunits are essential for cellular function. All six subunits are evolutionarily conserved in terms of sequence and their interactions with other subunits. The most striking features are the structural conservation of the protein complexes and the phenotypic similarity caused by loss-of-function mutations in any protein subunit. Similar to elongation factors in translation, there is a strong interaction between the Elongator complex and RNA polymerase II during transcription. The Elongator complex is also involved in a variety of cellular pathways, including histone modification/acetylation, DNA methylation, tRNA nucleoside modification, etc. Here, we summarized the functions and mechanisms of the Elongator complex in plant growth and development, molecular pathways, and gene regulation. In this way, we aimed to provide a reference for an in-depth study of the Elongator complex.

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Published

2023-03-27

How to Cite

XIANGZHUO, J., ZELONG, Z., YINXIA, W., YUNFANG, Z., & YUNLING, P. (2023). Research progress of the Elongator complex in plant. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 51(1), 13058. https://doi.org/10.15835/nbha51113058

Issue

Vol. 51 No. 1 (2023)

Section

Review Articles
CITATION
DOI: 10.15835/nbha51113058

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Copyright (c) 2023 Ji XIANGZHUO, Zhuang ZELONG, Wang YINXIA, Zhang YUNFANG, Peng YUNLING

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