Antioxidant and cytotoxic activities of Artemisia monosperma L. and Tamarix aphylla L. essential oils

  • Ramy M. ROMEILAH Hail University, College of Science, Department of Chemistry, Hail; Cairo University, Faculty of Agriculture, Department of Biochemistry, Giza, 12613 (SA)
  • Hossam S. EL-BELTAGI King Faisal University, College of Agriculture and Food Sciences, Agricultural Biotechnology Department, P.O. Box 420, Al-Ahsa 31982; Cairo University, Faculty of Agriculture, Department of Biochemistry, Giza, 12613 (SA)
  • Emad A. SHALABY Cairo University, Faculty of Agriculture, Department of Biochemistry, Giza, 12613 (EG)
  • Kareem M. YOUNES Hail University, College of Pharmacy, Department of Pharmaceutical Chemistry, Hail; Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Cairo (SA)
  • Hani EL MOLL Hail University, College of Science, Department of Chemistry, Hail (SA)
  • Saravanan RAJENDRASOZHAN Hail University, College of Science, Department of Chemistry, Hail (SA)
  • Heba MOHAMED Ain Shams University, Faculty of Education, Biological and Geological Sciences Department, Cairo (EG)
Keywords: antioxidant activity; Artemisia monosperma; cytotoxic activity; essential oil; Tamarix aphylla

Abstract

Essential (volatile) oil from leaves of Artemisia monosperma L. belonging to family Asteraceae, and aerial parts of Tamarix aphylla L. (Athel) belonging to family Tamaricaceae were collected from the desert of Ha'il region, northern region of Saudi Arabia, hydro distilled by Clevenger apparatus and analysed by means of GC-MS techniques. Antioxidant activities of essential oils of A. monosperma and T. aphylla compared with ascorbic acid and butylated hydroxytoluene (BHT) as reference antioxidant compound were determined by method of DPPH radical scavenging assay and ABTS assay. In vitro screening of potential cytotoxicity of essential oils was also evaluated against human promyelocytic leukaemia cell lines (HL60 and NB4). The GC/MS analysis of A. monosperma essential oil resulted in identification of 61 components predominated mainly by β-Pinene as principal component (29.87%) and T. aphylla resulted in identification of 37 components of essential oil predominated mainly by 6,10,14- trimethyl-2-pentadecanone (21.43%) as principal component. Antioxidant activity as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and 2,2 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) increased with increasing essential oil concentrations of A. monosperma and T. aphylla (25, 50, 75, 100 and 200 μg mL-1). The most pronounced increases detected in the high concentrations of the two essential oils. Biologically, essential oil extracts exhibited cytotoxicity effects in dose dependent manner against human promyelocytic leukaemia cell lines (HL60 and NB4). In conclusion, A. monosperma and T. aphylla essential oils could be valuable source for cytotoxic agents with high safety and selective cytotoxicity profiles.

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Published
2021-02-11
How to Cite
ROMEILAH, R. M., EL-BELTAGI, H. S., SHALABY, E. A., YOUNES, K. M., EL MOLL, H., RAJENDRASOZHAN, S., & MOHAMED, H. (2021). Antioxidant and cytotoxic activities of Artemisia monosperma L. and Tamarix aphylla L. essential oils . Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 49(1), 12233. https://doi.org/10.15835/nbha49112233
Section
Research Articles
CITATION
DOI: 10.15835/nbha49112233

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