Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science
Abstract
Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention from scientists due to its potent antimalarial properties as secondary metabolites. Moreover, more attentions are focusing on the roles of artemisinin and its derivatives in treating obesity and metabolic diseases. They also have anti-bacterial, anti-inflammatory, anti-tumor, anti-protozoa, anti-helminthic, anti-fungal, anti-angiogenic and antiproliferation properties. The most important derivatives of Artemisia annua L. are arteether, artemether, artemiside, artemisinin, artemisone, artesunate, and dihydroartemisinin. Artemisinin also use against some cancers such as liver cancer, brain glioma, leukemia, nasopharyngeal cancer, gallbladder cancer, gastric cancer, cervical cancer, lung cancer, breast cancer and colon cancer. This important gift from ancient Chinese traditional medicine can guarantee health of people all around the world. Further researches should be done on the new advances and development of artemisinin and its derivatives as potential natural medicine in the global fight against so many diseases, malaria included.
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References
Abba ML, Patil N, Leupold JH, Saeed MEM, Efferth T, Allgayer H (2018). Prevention of carcinogenesis and metastasis by Artemisinin-type drugs. Cancer Letters 429:11-18. http://doi.org/10.1016/j.canlet.2018.05.008
Abolaji AO, Eteng MU, Ebong PE, Dar A, Farombi EO, Choudhary MI (2014). Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model. Natural Product Research 28(24):2342-2346. http://doi.org/10.1080/14786419.2014.936016
Abou Rayia DM, Saad AE, Ashour DS, Oreiby RM (2017). Implication of artemisinin nematocidal activity on experimental trichinellosis: in vitro and in vivo studies. Parasitology International 66(2):56-63. http://doi.org/10.1016/j.parint.2016.11.012
Abubakar US, Yusuf KM, Abdullahi MS, Abdu GT, Abdulrazak A, Muhammad S, … Aliyu I (2018). Cultivation, phytochemical and in vitro anti-plasmodium activity of Artemisia annua L. (Asteraceae). Journal of Medicinal Plans Studies 6(4):151-155.
Aderibigbe BA (2017). Design of drug delivery systems containing artemisinin and its derivatives. Molecules 22:323. https://doi.org/10.3390/molecules22020323
Ahuja J, Suresh J, Paramakrishnan N, Mruthunjaya K, Naganandhini MN (2011). An ethnomedical, phytochemical and pharmacological profile of Artemisia parviflora Roxb. Journal of Essential Oil-Bearing Plants 14(6):647-657. https://doi.org/10.1080/0972060X.2011.10643985
Allam H, Benamar H, Mansour RB, Ksouri R, Bennaceur M (2019). Phenolic composition, antioxidant, and antibacterial activities of Artemisia judaica subsp. sahariensis. Journal of Herbs, Spices and Medicinal Plants 25(4):347-362. https://doi.org/10.1080/10496475.2019.1631928
Angus BJ, Thaiaporn I, Chanthapadith K, Suputtamongkol Y, White NJ (2002). Oral artesunate dose-response relationship in acute Falciparum malaria. Antimicrobial Agents and Chemotherapy 46:778-782. https://doi.org/10.1128/AAC.46.3.778-782.2002
Aquino I, Perazzo FF, Maistro EL (2011). Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice. Food and Chemical Toxicology 49:1335-1339. https://doi.org/10.1016/j.fct.2011.03.016
Asano M, Iwahashi H (2017). Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions. European Journal of Medicinal Chemistry 127:740-747. https://doi.org/10.1016/j.ejmech.2016.10.053
Ashok PK, Upadhyaya K (2013). Evaluation of analgesic and anti-inflammatory activities of aerial parts of Artemisia vulgaris L. in experimental animal models. Journal of Biologically Active Products from Nature 3(1):101-105. https://doi.org/10.1080/22311866.2013.782761
Ashraf A, Sarfraz RA, Mahmood A (2017). Phenolic compounds, characterization of Artemisia rutifolia spreng from Pakistani flora and their relationships with antioxidant and antimicrobial attributes. International Journal of Food Properties 20(11):2538-2549. https://doi.org/10.1080/10942912.2016.1243556
Asili J, Emami SA, Eynolghozat R, Noghab ZS, Bazzaz BSF, Sahebkar A (2015). Chemical composition and in vitro efficacy of essential oil of seven Artemisia species against ESBL producing multidrug-resistant Escherichia coli. Journal of Essential Oil-Bearing Plants 18(1):124-145. https://doi.org/10.1080/0972060X.2014.895181
Atemnkeng MA, Chimanuka B, Dejaegher B, Heyden YV, Plaizier-Vercammen J (2009). Evaluation of Artemisia annua infusion efficacy for the treatment of malaria in chabaudi Plasmodium chabaudi infected mice. Experimental Parasitology 122(4):344-348. https://doi.org/10.1016/j.exppara.2009.04.004
Baldino L, Reverchon E, Porta GD (2017). An optimized process for SC-CO2 extraction of antimalarial compounds from Artemisia annua L. The Journal of Supercritical Fluids 128:89-93. https://doi.org/10.1016/j.supflu.2017.05.018
Beekman AC, Wierenga PK, Woerdenbag HJ, Van Uden W, Pras N, KoningsAW, … Wikstrom HV (1998). Artemisinin-derived sesquiterpene lactones as potential antitumor compounds: cytotoxic action against bone marrow and tumour cells. Planta Medica 64:615-619. https://doi.org/10.1055/s-2006-957533
Behravan J, Ramezani M, Hassanzadeh MK, Eliaspour N, Sabeti Z (2006). Cytotoxic and antimycotic activities of essential oil from Artemisia turanica Krasch from Iran. Journal of Essential Oil-Bearing Plants 9(2):196-203. https://doi.org/10.1080/0972060X.2006.10643492
Bhakuni RS, Jain DC, Sharma RP, Kumar S (2001). Secondary metabolites of Artemisia annua and their biological activity. Current Science 80:35-48.
Bigoniya P, Sahu T, Tiwari V (2015). Hematological and biochemical effects of sub-chronic artesunate exposure in rats. Toxicology Reports 2:280-288. https://doi.org/10.1016/j.toxrep.2015.01.007
BiliaAR, Melillo de Malgalhaes P, Bergonzi MC, Vincieri FF (2006). Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine 13:487-493. https://doi.org/10.1016/j.phymed.2006.01.008
Bora KS, Sharma A (2011). Evaluation of antioxidant and free-radical scavenging potential of Artemisia absinthium. Pharmaceutical Biology 49(12):1216-1223. https://doi.org/10.3109/13880209.2011.578142
Bourgou S, Tammar S, Salem N, Mkadmini K, Msaada K (2016). Phenolic composition, essential oil, and antioxidant activity in the aerial part of Artemisia Herba-Alba from several provenances: A comparative study. International Journal of Food Properties 19(3):549-563. https://doi.org/10.1080/109422912.2015.1040495
Brisibe EA, Udensi O, Chukwurah PN, de Magalhaes PM, Figueira GM, Ferreira JFS (2012). Adaptation and agronomic performance of Artemisia annua L. under lowland humid tropical conditions. Industrial Crops and Products 39:190-197. https://doi.org/10.1016/j.indcrop.2012.02.018
Cai T-Y, Zhang Y-R, Ji J-B, Xing J (2017). Investigation of the component in Artemisia annua L. leading to enhanced antiplasmodial potency of artemisinin via regulation of its metabolism. Journal of Ethnopharmacology 207:86-91. https://doi.org/10.1016/j.jep.2017.06.025
Carbonara T, Pascale R, Argentieri MP, Papadia P, Fanizzi FP, Villanova L, Avato P (2012). Phytochemical analysis of a herbal tea from Artemisia annua L. Journal of Pharmaceutical and Biomedical Analysis 65:79-86. http://doi.org/10.1016/j.jpba.2012.01.015
Cavar S, Maksimovic M, Vidic D, Paric A (2012). Chemical composition and antioxidant and antimicrobial activity of essential oil of Artemisia annua L. from Bosnia. Industrial Crops and Products 37(1):479-485. https://doi.org/10.1016/j.indcrop.2011.07.024
Charles DJ, Cebert E, Simon JE (1991). Characterization of the essential oil of Artemisiaannua L. Journal of Essential Oil Research 3(1):33-39. https://doi.org/10.1080/10412905.1991.9697903
Chen J, Zhang L, Hao M (2018). Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro. Saudi Journal of Biological Sciences 25:1488-1493. https://doi.org/10.1016/j.sjbs.2018.04.003
Christian J, Shah P, Patel M, Patel K, Ganghi T (2017). Optimizing derivatization conditions using an experimental design and simultaneous estimate of artemether and lumefantrine by ratio first order derivative spectrophotometric method. Journal of Taibah university for Science 11(5):729-740. https://doi.org/10.1016/j.jtusci.2016.08.003
Correa-Ferreira ML, Viudes EB, De MagalhaesPM, Filho APDS, Sassaki GL, Pacheco AC, Petkowicz CLDO (2019). Changes in the composition and structure of cell wall polysaccharides from Artemisia annua in response to salt stress. Carbohydrate Research 483:107753. https://doi.org/10.1016/j.carres.2019.107753
Crespo MP, Wei MQ (2012). Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. Journal of Biomedicine and Biotechnology 2(4):247597. https://doi.org/10.1155/2012/247597
Daddy NB, Kalisya LM, Bagire PG, Watt RL, Towler MJ, Weathers PJ (2017). Artemisia annua dried leaf tablets treated malaria resistant to ACT and i.v. artesunate: case reports. Phytomedicine 32(15):37-40. https://doi.org/10.1016/j.phymed.2017.04.006
Davies MJ, Atkinson CJ, Burns C, Arroo R, Woolley J (2011). Increases in leaf artemisinin concentration in Artemisia annua in response to the application of phosphorus and boron. Industrial Crops and Products 34(3):1465-1473. https://doi.org/10.1016/j.indcrop.2011.05.002
DelabaysN, Simonnet X, Gaudin M (2001). The genetics of artemisnin content in Artemisia annua L. and the breeding of high yielding cultivars. Current Medicinal Chemistry 8:1795-1801. https://doi.org/10.2174/0929867013371635
De Oliveira TC, Silva DA, Rostkowska C, Bela SR, Ferro EA, Magalhaes PM, Mineo JR (2009). Toxoplasma gondii: effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo. Experimental Parasitology 122:233-241. https://doi.org/10.1016/j.exppara.2009.04.010
Donato R, Santomauro F, Bilia AR, Flamini G, Sacco C (2015). Antibacterial activity of Tuscan Artemisia annua essential oil and its major components against some foodborne pathogens. LWT-Food Science and Technology 64:1251-1254. https://doi.org/10.1016/j.lwt.2015.07.014
Efferth T (2017). From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy. Seminars in Cancer Biology 46:65-83. https://doi.org/10.1016/j.semcancer.2017.02.009
El-Askary H, Handoussa H, Badira F, El-Khatib AH, Alsayari A, Linscheid MW, Motaal AA (2019). Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS-MS. Revista Brasileira de Farmacognosia 29:213-220. https://doi.org/10.1016/j.bjp.2018.10.001
El-Naggar EB, Azazi M, Svajdlenka E, Zemlicka M (2013). Artemisinin from minro to major ingredient in Artemisia annua cultivated in Egypt. Journal of Applied Pharmaceutical Science 3(08):116-123.
Fathy FM (2011). Anthelmintic effect of artesunate in experimental heterophyid infection. Journal of the Egyptian Society of Parasitology 41:469-483.
Ferreira JFS, Luthria DL, Sasaki T, Heyerick A (2010). Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules 15(5):3135-3170. https://doi.org/10.3390/molecules15053135
Fu J-E, Feng L, Wei S-G, Ma X-J, Huang E-S, Feng S-X, Dong Q-S, Yan Z-G (2016). Distinctive morphological characteristics contribute to the identification of Artemisia annua L. germplasms with high yield and high artemisinin content. Journal of Applied Research on Medicinal and Aromatic Plants 3:43-47. https://doi.org/10.1016/j.jarmap.2015.12.004
Fu C, Yu P, Wang M, Qiu F (2020). Phytochemical analysis and geographic assessment of flavonoids, coumarins and sesquiterpenes in Artemisia annua L. based on HPLC-DAD quantification and LC-ESI-QTOF-MS/MS confirmation. Food Chemistry 312:126070. https://doi.org/10.1016/j.foodchem.2019.126070
Garah FBE, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL… O,Neill PM (2011). Comparison of the reactivity of antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salt/phosphatidylcholine. Journal of Medicinal Chemistry 54:6442-6455. https://doi.org/10.1021/jm200768h
Ghafoori H, Sariri R, Naghavi MR, Aryakia E, Dolatyari A, Shahzadeh FSA, … Farahmand Z (2013). Analysis of artemisinin isolated from Artemisia annua L. by TLC and HPLC. Journal of Liquid Chromatography and Related Technologies 36(9):1198-1206.
Goel D, Mallavarupu GR, Kumar S, Singh V, Ali M (2008). Volatile metabolite compositions of the essential oil from aerial parts of ornamental and artemisinin rich cultivars of Artemisia annua. Journal of Essential Oil Research 20(2):147-152. https://doi.org/10.1080/10412905.2008.9699976
Goswami P, Chauhan A, Verma RS, Padalia R, Verma SK, Darokar MP, Chanotuya CS (2016). Composition and antibacterial activity of the essential oil of Artemisia nilagirica var. septentrionalis from India. Journal of Essential Oil Research 28(1):71-76. https://doi.org/10.1080/10412905.2015.1083489
Gouveia SC, Castilho P (2013). Artemisia annua L.: Essential oil and acetone extract composition and antioxidant capacity. Industrial Crops and Products 45:170-181. https://doi.org/10.1016/j.indcrop.2012.12.022
Gugliandolo E, D,Amico R, Cordaro M, Fusco R, Siracusa R, Crupi R (2018). Neuroprotective effect of artesunate in experimental model of traumatic brain injury. Frontiers in Neurology 9:590. https://doi.org/10.3389/fneur.2018.00590
Habibi Z, Ghanian S, Ghasemi S, Yousefi M (2013). Chemical composition and antibacterial activity of the volatile oil from seeds of Artemisia annua L. from Iran. Natural Product Research 27(2):198-200. https://doi.org/10.1080/14786419.2012.662652
Hethelyi EB, Cseko IB, Grosz M, Mark G, Palinkas JJ (1995). Chemical composition of the Artemisia annua essential oils from Hungary. Journal of Essential Oil Research 7(1):45-48.
Ho WE, Peh HY, Chan TK, Wong WS (2014). Artemisinins: pharmacological actions beyond anti-malaria. Pharmacology and Therapeutics 142(1):126-139. https://doi.org/10.1080/10412905.1995.9698460
Hou L, Huang H (2016). Immune suppressive properties of artemisinin family drugs. Pharmacology and Therapeutics 166:123-127. https://doi.org/10.1016/j.pharmthera.2016.07.002
Huang L, Xie C, Duan B, Chen S (2010). Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system. Chinese Medicine 5:18. https://doi.org/10.1186/1749-8546-5-18
Huo J, Lu Y, Xia L, Chen D (2020). Structural characterization and anticomplement activities of three acidic homogenous polysaccharides from Artemisiaannua. Journal of Ethnopharmacology 247:112281. https://doi.org/10.1016/j.jep.2019.112281
IkramNKBK, Simonsen HT (2017). A review of biotechnological artemisinin production in plants. Frontiers in Plant Science. Volume 8, Article 1966. https://doi.org/10.3389/fpls.2017.01966
Ivanescu B, Vlase L, Corciova A, Lazar MI (2011). Artemisinin evaluating in Romanian Artemisia annua wild plants using a new HPLC/MC method. Natural Prodcut Research 25(7):716-722. https://doi.org/10.1080/14786410903169847
Jain N, Srivastava SK, Aggarwal KK, Kumar S, Syamasundar KV (2002). Essential oil composition of Artemisia annua L. ʻAshaʼ from the plains of Northern India. Journal of Essential Oil Research 14(4):305-307. https://doi.org/10.1080/10412905.2002.9699863
Jiang Y, Du H, Liu X, Fu X, Li X, Cao Q (2020). Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-κB/NLRP3 inflammasomes pathway. Journal of Drug Targeting 28(1):70-79. https://doi.org/10.1080/1061186X.2019.1616296
Kannan D, Yadav N, Ahmad S, Namdev P, Bhattacharjee S, Lochab B, Singh S (2019). Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite. EBioMedicine 45:261-277. https://doi.org/10.1016/j.ebiom.2019.06.026
Kazemi M, Dakhili M, Davari M (2012). Constituents and antimicrobial activity of essential oil of Artemisia lehmanniana Bunge from Iran. Journal of Essential Oil-Bearing Plants 15(3):392-398. https://doi.org/10.1080/0972060X.2012.10644066
Kazemi M (2015). Essential oil of the aerial parts of Artemisia annua (Asteraceae) from Iran. Journal of Essential Oil-Bearing Plants 18(4):1003-1005. https://doi.org/10.1080/0972060X.2014.931256
Keiser J, Ingram K, Vargas M, Chollet J, Wang X, Dong Y, Vennerstrom JL (2012). In vivo activity of aryl ozonides against Schistosoma species, Antimicrob. Agents Chemother 56(2):1090-1092. https://doi.org/10.1128/AAC.05371-11
Komori A, Suzuki A, Seki H, Nishizawa T, Meyer JJM, Shimizu H, … Muranaka T (2013). Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4, 11-diene. FEBS Letters 587:278-284. https://doi.org/10.1016/j.febslet.2012.11.031
Kong Z, Liu R, Cheng Y(2019). Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomedicine and Pharmacotherapy 109:2043-2053. https://doi.org/10.1016/j.biopha.2018.11.030
Konstat-Korzenny E, Ascencio-Aragon JA, Niezen-Lugo S, Vazquez-Lpoez R (2018). Artemisinin and its synthetic derivatives as a possible therapy for cancer. Medical Sciences 6:19. https://doi.org/10.3390/medsci6010019
Koul B, Taak P, Kumar A, Khatri T, Sanyal I (2017). The Artemisia genus: a review of traditional uses, phytochemical constituents, pharmacological properties and germplasm conservation. Journal of Glycomics & Lipidomics 7:1. https://doi.org/10.4172/2153-0637.1000142
Krishna S, Ganapathi S, Ster IC, Saeed MEM, Cowan M, Finlayson C, … Kumar D (2015). A randomized, double blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer. EBioMedicine 2:82-90. https://doi.org/10.1016/j.ebiom.2014.11.010
Kuster T, Kriegel B, Stadelmann X, Wang Y, Dong JL, VennerstromJ, … Hemphill A (2014). Hempill, Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International Journal of Antimicrobial Agents 43(1):40-46. https://doi.org/10.1016/j.ijantimicag.2013.09.012
Lai H, Sasaki T, Singh NP (2005). Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. Expert Opinion on Therapeutic Targets 9(5):995-1007. https://doi.org/10.1517/14728222.9.5.995
Lai HC, Singh NP, Sasaki T (2013). Development of artemisinin compounds for cancer treatment. Investigation New Drugs 31:230-246. https://doi.org/10.1007/s10637-012-9873-z
Lam NS, Long X, Su X-Z, Lu F (2018). Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis. Pharmacological Research133:77-100. https://doi.org/10.1016/j.phrs.2018.04.025
Lang SJ, Schmiech M, Hafner S, Paetz C, Steinborn C, Huber R, … Simmet T (2019). Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomedicine 62:152962. https://doi.org/10.1016/j.phymed.2019.152962
Lee J-H (2016). Antibacterial activity against oral pathogens and anti-oral cancer activity of Artemisia species in vitro. Journal of Herbs, Spices and Medicinal Plants 22(2):130-138. https://doi.org/10.1080/10496475.2015.1091424
Li Y-J, Guo Y, Yang Q, Weng X-G, Yang L, Wang Y-J, … Zidek Z (2015). Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicology and Applied Phamacology 286(3):151-158. https://doi.org/10.1016/j.taap.2015.04.005
Li Y, Xia L, Vazquez JFT, Song S (2017). Optimization of supercritical CO2 extraction of essential oil from Artemisia annua L. by means of response surface methodology. Journal of Essential Oil-Bearing Plants 20(2):314-327. https://doi.org/10.1080/0972060X.2017.1298475
Li J, Wang B, Luo Y, Bian Y, Wang R (2018). Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model. Allergy, Asthma & Clinical Immunology 14:22.
Li K-M, Dong X, Ma Y-N, Wu Z-H, Yan Y-M, Cheng Y-X (2019). Antifungal coumarins and lignans from Artemisia annua. Fitoterapia 134:323-328.
Li X, He J, Lian Y, Li F, Suo, Jin G (2020). The complete chloroplast genome sequence of Artemisia ordosica. Mitochondrial DNA Part B 5(3):2180-2181.
Libbey LM, Sturtz G (1989). Unusual essential oils grown in Oregon II. Artemisia annua L. Journal of Essential Oil Research 1(5):201-202.
Lim CE, Kim G-B, RyuS-A, Yu H-J, Mun J-H (2018). The complete chloroplast genome of Artemisia hallaisanensis Nakai (Asteraceae) and endemic medicinal herb in Korea. Mitochondrial DNA Part B 3(1):359-360. https://doi.org/10.1080/23802359.2018.1450680
Lima B, de Lampasona MP, Schuff C, Tapia A, Bomben R, Duschatzky C, Feresin GE (2008). Chemical composition and antibacterial activity of Artemisia mendozana D. C. essential oil. Journal of Essential Oil-Bearing Plants 11(5):496-502. https://doi.org/10.1080/0972060X.2008.10643658
Lin W, Heimbach T, Jain JP, Awasthi R, Hamed K, Sunkara G, He H (2016). A physiologically based pharmacokinetic model to describe artemether pharmacokinetics in adult and pediatric patients. Journal of Pharmaceutical Sciences 105:3205-3213. https://doi.org/10.1016/j.xphs.2016.06.026
Liu H, Tian X, Zhang Y, Wang C, Jiang H (2013). The discovery of Artemisia annua L. in the Shengjindian cemetery, Xinjiang, China and its implications for early uses of traditional Chinese herbal medicine qinghao. Journal of Ethnopharmacology 146(1):278-286. https://doi.org/10.1016/j.jep.2012.12.044
Liu H, Guo S-S, Lu L, Li D, Liang J, Huang Z-H, … Du S (2019). Essential oil from Artemisia annua aerial parts: composition and repellent activity against two storage pests. Natural Product Research. https://doi.org/10.1080/14786419.2019.1599887
Lohani H, Gwari G, Bhandari U, Haider SZ, Andola H, Chauhan N (2016). Variability in the essential oils from aerial parts of Artemisia vulgaris L. grown in Uttarakhand (India). Journal of Essential Oil-Bearing Plants 19(1):103-107. https://doi.org/10.1080/0972060X.2015.1127784
Lu Z-H, Peng J-H, Zhang R-X, Wang F, Sun H-P, Fang Y-J, … Pan Z-Z (2018). Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARγ expression. Saudi Journal of Biological Sciences 25:327-376. https://doi.org/10.1016/j.sjbs.2017.02.002
Lu F, He X-L, Richard C, Cao J (2019). A brief history of artemisinin: modes of action and mechanisms of resistance. Chinese Journal of Natural Medicines 17(5):0331-0336. https://doi.org/10.1016/S1875-5364(19)30038-X
Lu K, Mao W, Du Z, He Y, Fan C, Zhang K, … Duan Y (2020). The complete chloroplast genome sequence of Artemisia ordosica. Mitochondrial DNA Part B 5(2):1663-1664. https://doi.org/10.1080/23802359.2020.1748530
Lubbe A, Seibert I, KlimkaitT, Van der Kooy F (2012). Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua. Journal of Ethnopharmacology 141(3):854-859. https://doi.org/10.1016/j.jep.2012.03.024
Lv Z, Zhang L, Tang K (2017). New insights into artemisinin regulation. Plant Signaling and Behavior 12(10):e1366398. https://doi.org/10.1080/15592324.2017.1366398
Lv Z, Zhang L, Chen L, Zhang F, Tang K (2018). The Artemisia annua flowering locust homolog 2, AaFT2, is a key regulator of flowering time. Plant Physiology and Biochemistry 126:197-205. https://doi.org/10.1016/j.plaphy.2018.02.033
Lv Z, Wang Y, Liu Y, Peng B, Zhang L, Tang K, Chen W (2019). The SPB-box transcription factor AaSPL2 positively regulates artemisinin biosynthesis in Artemisia annua L. Frontiers in Plant Science. Volume 10, Article 409. https://doi.org/10.3389/fpls.2019.00409
Ma C, Wang H, Lu X, Li H, Liu B, Xu G (2007). Analysis of Artemisia annua L. volatile oil by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Chromatography A 1150(1-2):50-53. https://doi.org/10.1016/j.chroma.2006.08.080
Madbouly NA, Shalash IR, El Deeb SO, El Amir AM (2015). Effect of artemether on cytokine profile and egg induced pathology in murine Schistosomiasis mansoni. Journal of Advanced Research 6:851-857. https://doi.org/10.1016/j.jare.2014.07.003
Magenta D, Sangiovanni E, Basilico N, Haynes RK, Parapini S, Colombo E, … Dell,Agli M(2014). Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Tropica 140:77-83. https://doi.org/10.1016/j.actatropica.2014.08.008
Magoulas GE, Tsigkou T, Skondra L, Lamprou M, TsoukalaP, Kokkinogouli V, Pantazaka E, Papioannou D, Athanassopoulos CM, Papadimitriou E (2017). Synthesis of novel artemisinin dimmers with plyamine linkers and evaluation of their potential as anticancer agents. Bioorganic and Medicinal Chemistry 25:2756-3767. https://doi.org/10.1016/j.bmc.2017.05.018
Malik AA, Ahmad J, Mir SR, Ali M, Abdin MZ (2009). Influence of chemical and biological treatments on volatile oil composition of Artemisia annua Linn. Industrial Crops and Products 30(3):380-383. https://doi.org/10.1016/j.indcrop.2009.07.006
Meshnick SR, TaylorTE, Kamchonwongpaisan S (1996). Artemisinin and the anti-malarial endoperoxides from herbal remedy to targeted chemotherapy. Microbiological Reviews 60(2):301-315. https://doi.org/10.1128/MMBR.60.2.301-315.1996
Messaili S, Colas C, Fougere L, Destandau E (2020). Combination of molecular network and centrifugal partition chromatography fraction for targeting and identifying Artemisia annua L. antioxidant compounds. Journal of Chromatography A 1615:460785. https://doi.org/10.1016/j.chroma.2019.460785
MirzaeeH, Sharafi A, Sohi HH (2016). In vitro regeneration and transient expression of recombinant sesquiterpene cyclase (SQC) in Artemisia annua L. South African Journal of Botany 104:225-231. https://doi.org/10.1016/j.sajb.2015.10.005
Mishina YV, Krishna S, Hynes RK, Meade JC (2007). Artemisinins inhibit Trypanosoma cruzi and Trypanosoma bruceirhodesiense in vitro growth. Antimicrobial Agents and Chemotherapy 51:1852-1854. https://doi.org/10.1128/AAC.01544-06
Mohamed TA, Hegazy M-EF, El Aty AAA, Ghabbour HA, Alsaid MS, Shahat AA, Pare PW (2017). Antimicrobial sesquiterpene lactones from Artemisiasieberi. Journal of Asian Natural Products Research 19(11):1093-1101. https://doi.org/10.1080/10286020.2017.1302939
Mohammadi A, Arianfar A, Noori M (2017). Chemical composition, antioxidant and antibacterial activity of Artemisia diffusa essential oil. Journal of Essential Oil-Bearing Plants 20(5):1235-1243. https://doi.org/10.1080/0972060X.2017.1345329
Moon H-I, Jung S, Lee Y-C, Lee J-H (2012). Anticomplement activity of various solvent extracts from Korea local Artemisia spp. Immunopharmacology and Immunotoxicology 34(1):95-97. https://doi.org/10.3109/08923973.2011.581286
Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L (2004). Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Transactions of the Royal Society of tropical Medicine and Hygiene 98(5):318-321. https://doi.org/10.1016/j.trstmh.2003.09.001
Munyangi J, Cornet-Vernet L, Idumbo M, Lu C, Lutgen P, Perronne C, … Weathers P (2018). Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine 51:233-240. https://doi.org/10.1016/j.phymed.2018.10.014
Munyangi J, Cornet-Vernet L, Idumbo M, Lu C, Lutgen P, Perronne C, … Weathers P (2019). Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial. Phytomedicine 57:49-56. https://doi.org/10.1016/j.phymed.2018.12.002
NaB J, Efferth T (2019). Development of artemisinin resistance in malaria therapy. Pharmacological Research 146:104275. https://doi.org/10.1016/j.phrs.2019.104275
Negi AS, Cortesi A, Kikic I, Bertucco A, Calabrese M, Solinas D (2018). Desorption of artemisinin extracts of CIM-Arogya by supercritical carbon dioxide. The Journal of Supercritical Fluids 133:42-48. https://doi.org/10.1016/j.supflu.2017.09.024
Njuguna NM, Ongarora DS, Chibale K (2012). Artemisinin derivatives: a patent review (2006 – present). Expert Opinion on Therapeutic Patents 22:1179-1203. https://doi.org/10.1517/13543776.2012.724063
Nosten F, White NJ (2007). Artemisinin-based combination treatment of falciparum malaria. The American Journal of Tropical Medicine and Hygiene 77(6):181-192. https://doi.org/10.4269/ajtmh.2007.77.181
Noubiap JJ (2014). Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: saving more lives. Journal of Infection and Public Health 7:407-412. https://doi.org/10.1016/j.jiph.2014.04.007
O,Neill P (2005). The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion on Investigational Drugs 14(9):1117-1128. https://doi.org/10.1517/13543784.14.9.1117
Omar AM, Dibwe DF, Tawila AM, Sun S, Kim MJ, Awale S (2019). Chemical constituents from Artemisia vulgaris and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. Natural Product Research. https://doi.org/10.1080/14786419.2019.1700246
Pan WS, Zheng LP, Tian H, LiWY, Wang JW (2014). Transcriptome responses involved in artemisinin production in Artemisia annua L. under UV-B radiation. Journal of Photochemistry and Photobiology B: Biology 140:292-300. https://doi.org/10.1016/j.jphotobiol.2014.08.013
Phyo AP, Win KK, Thu AM, Swe LL, Htike H, Beau C, … Nosten F (2018). Poor response to artesunate treatment in two patients with severe malaria on the Thai-Myanmer border. Malaria Journal 17:30. https://doi.org/10.1186/s12936-018-2182-z
Posner GH, D,Angelo J, O,Neill PM, Mercer A (2006). Anticancer activity of artemisinin-derived trioxanes. Expert Opinion on Therapeutic Patents. 16(12):1665-1672. https://doi.org/10.1517/13543776.16.12.1665
Price RN (2000). Artemisinin drugs: novel antimalarial agents. Expert Opinion on Investigational Drugs 9(8):1815-1827. https://doi.org/10.1517/13543784.9.8.1815
Qiang W, Cai W, Yang Q, Yang L, Dai Y, Zhao Z, … Zhu X (2018). Artemisinin B improves learning and memory impairment in AD dementia mice by suppressing neuroinflammation. Neuroscience 395:1-12. https://doi.org/10.1016/j.neuroscience.2018.10.041
Qiu F, Wu S, Lu X, Zhang C, Li J, Gong M, Wang M (2018). Quality evaluation of the artemisinin-producing plants Artemisia annua L. based on simultaneous quantification of artemisinin and six synergistic components and hierarchical cluster analysis. Industrial Crops and Products 118:131-141. https://doi.org/10.1016/j.indcrop.2018.03.043
Rafika G, Zahia H, Nesma H (2018). Chemical composition and antibacterial activity of Artemisia campestris spp. glutinosa (J. Gay) Batt. and A. judaica spp. sahariensis (Chev.) species endemic to the Algerian Sahara. Journal of Essential Oil-Bearing Plants 21(3):779-788. https://doi.org/10.1080/0972060X.2018.1484819
Rahman SU, Khalid M, Kayani SI, Jan F, Ullah A, Tang K (2019). Biological activities artemisinins beyond anti-malarial: a review. Tropical Plant Biology. https://doi.org/10.1007/s12042-019-09228-0
Ram M, Jain DC, MishraH, Mandal S, Abdin MZ (2014). Recent advances to enhance yield of artemisinin: a novel antimalarial compound. Artemisia annua L. plants. Springer-Verlag, Berlin Heidelberg. http://dx.doi.org.10.1007/978-3-642-41027-7-11.
Ranjbar M, Naghavi MR, Alizadeh H (2020). Chemical composition of the essential oils of Artemisia species from Iran: a comparative study using multivariate statistical analysis. Journal of Essential Oil Research. https://doi.org/10.1080/10412905.2020.1750495
Rao BRR, Syamasundar KV, Patel RP (2014). Effects of method of distillation on the yield and chemical composition of Artemisia annua essential oil. Journal of Essential Oil Research 26(6):486-491. https://doi.org/10.1080/10412905.2014.949881
Rassias DJ, Weathers PJ (2019). Dried leaf Artemisia annua efficacy against non-small cell lung cancer. Phytomedicine 52:247-253. https://doi.org/10.1016/j.phymed.2018.09.167
Rath K, Taxis K, Walz G, Gleiter CH, Li S-M, Heide L (2004). Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). The American Journal of Tropical Medicine and Hygiene 70(2):128-132. https://doi.org/10.4269/ajtmh.2004.70.128
Saleh MA, Belal MH, El-Baroty G (2006). Fungicidal activity of Artemisiaherba alba Asso (Asteraceae). Journal of Environmental Science and Health, Part B 41(3):237-244. https://doi.org/10.1080/03601230500354774
Salehi M, Karmizadeh G, Naghavi MR, Naghdi Badi H, Rashidi Monfared S (2018). Expression of artemisinin biosynthesis and trichome formation genes in five Artemisia species. Industrial Crops and Products 112:130-140. https://doi.org/10.1016/j.indcrop.2017.11.002
Sarder A, Pokharel YR (2018). Synthetic derivatives of artemisinin and cancer. International Journal of Medicine and Biomedical Sciences 1:54-58.
Sekiou O, Boumendjel M, Taibi F, Boumendjel A, Messarah M (2019). Mitigating effects of antioxidant properties of Artemisia herba alba aqueous extract on hyperlipidemia and oxidative damage in alloxan-induced diabetic rats. Archives of Physiology and Biochemistry 125(2):163-173. https://doi.org/10.1080/13813455.2018.1443470
Shahrajabian MH, Sun W, Cheng Q(2019a). Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agriculturae Scandinavica, Section B-Soil & Plant Science 1-11. https://doi.org/10.1080/09064710.2019.1606930
Shahrajabian MH, Sun W, Cheng Q (2019b). A review of ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science. Journal of Medicinal Plants Research 13(10):213-226.
Shahrajabian MH, Sun W, Cheng Q (2019c). Modern pharmacological actions of longan fruits and their usages in traditional herbal remedies. Journal of Medicinal Plants Studies 7(4):179-185.
Shahrajabian MH, Sun W, Cheng Q (2019d). DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine. Journal of Medicinal Plants Research 13(16):357-369. https://doi.org/10.5897/JMPR2019.6803
Shahrajabian MH, Sun W, Shen H, Cheng Q (2020a). Chinese herbal medicine for SARS and SARS-CoV-2 treatment and prevention, encouraging using herbal medicine for COVID-19 outbreak. Acta Agriculturae Scandinavica, Section B- Soil & Plant Science. https://doi.org/10.1080/09064710.2020.1763448
Shahrajabian MH, Sun W, Cheng Q (2020b). Chinese star anise (Illicium verum) and pyrethrum (Chrysanthemum cinerariifolium) as natural alternatives for organic farming and health care- A review. Australian Journal of Crop Sciences 14(03):517-523. https://doi.org/10.21475/ajcs.20.14.03.p2209
Shahrajabian MH, Sun W, Cheng Q (2020c). Considering white gold, cotton for its fiber, seed oil, traditional and modern health benefits. Journal of Biological and Environmental Sciences 14(40):25-39.
Shahrajabian MH, Sun W, Cheng Q (2020d). Chinese onion, and shallot, originated in Asia, medicinal plants for healthy daily recipes. Notulae Scientia Biologicae 12(2):197-207. https://doi.org/10.15835/nsb12210725
Shatar S, Dung NX, Karashawa D (2003). Essential oil composition of some Mongolian Artemisia species. Journal of Essential Oil-Bearing Plants 6(3):203-206. https://doi.org/10.1080/0972-060X.2003.10643353
ShenQ, Yan T, Fu X, Tang K (2016). Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L. Science Bulletin 61(1):18-25. https://doi.org/10.1007/s11434-015-0983-9
Shen Q, Zhang K, Liao Z, Wang S, Yan T, Shi P, … Tang K (2018). The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis. Molecular Plant 11:776-788. https://doi.org/10.1016/j.molp.2018.03.015
Shi C, Li H, Yang Y, Hou L (2015). Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives. Mediators of Inflammation 2015:435713. https://doi.org/10.1155/2015/435713
Shi Z, Chen Y, Lu C, Dong L-M, Lv J-W, Tuo Q-H, … Liu X-M (2018). Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin. Pharmacological Research 136:172-180. https://doi.org/10.1016/j.phrs.2018.09.002
Song Z, Cheng K, Zhang L, Wang T (2017). Dietary supplementation of enzymatically treated Artemisia annua could alleviate the intestinal inflammatory response in heat-stressed broilers. Journal of Thermal Biology 69:184-190. https://doi.org/10.1016/j.jtherbio.2017.07.015
Stojanovic G, Palic R, Mitrovic J, Djokovic D (2000). Chemical composition and antimicrobial activity of the essential oil of Artemisia lobelii all. Journal of Essential Oil Research 12(5):621-624. https://doi.org/10.1080/10412905.2000.9712172
Sulsen V, Frank FM, Cazorla SI, Anesini CA, Malchiodi EL, Fleixa B, … Martino VS (2008). Trypanocidal and leishmanicidal activities of sesquiterpene lactones from Ambrosia tenuifolia Sprengel (Asteraceae). Antimicrobial Agents and Chemotherapy 52:2415-2419. https://doi.org/10.1128/AAC.01630-07
Sulsen V, Gutierrez Yappu D, Laurella L, Anesini C, Gimenez Turba A, Martino V, Muschietti L (2011). In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia. Evidence-Based Complementary and Alternative Medicine 2011:352938. https://doi.org/10.1155/2011/352938
Sun W, Shahrajabian MH, Cheng Q (2019a). The insight and survey on medicinal properties and nutritive components of shallot. Journal of Medicinal Plant Research 13(18):452-457. https://doi.org/10.5897/JMPR2019.6836
Sun W, Shahrajabian MH, Cheng Q (2019b). Anise (Pimpinella anisum l.), a dominant spice and traditional medicinal herb for both food and medicinal purposes. Cogent Biology 5(1673688):1-25. https://doi.org/10.1080/23312025.2019.1673688
Sun W, Shahrajabian MH, Khoshkharam M, Cheng Q (2020a). Adaptation of acupuncture and traditional Chinese herbal medicines because of climate change. Journal of Stress Physiology and Biochemistry 16(1):85-90.
Sun W, Shahrajabian MH, Cheng Q (2020b). Pyrethrum an organic and natural pesticide. Journal of Biological and Environmental Sciences 14(40):41-44.
Suresh J, Mahesh NM, Ahuja J, Santilna KS (2011). Review on Artemisia nilagirica (Clarke) pamp. Journal of
Biologically Active Products from Nature 1(2):97-104. https://doi.org/10.1080/22311866.2011.10719075
Tadayoni Z, Shafaroodi H, Asgarpanah J (2018). Analgesic and anti-inflammatory activities of the essential oil from Artemisia aucheri Boiss. Journal of Essential Oil-Bearing Plants 21(2):440-448. https://doi.org/10.1080/0972060X.2017.1396929
Taherkhani M (2015). Anti-cancer, cytotoxic activity, mutagenic and anti-mutagenic activities of Artemisia aucheri essential oil. Journal of Essential Oil-Bearing Plants 18(6):1329-1337. https://doi.org/10.1080/0972060X.2014.1000388
Tu Y (2016). Artemisinin-a gift from traditional Chinese medicine to the world (nobel lecture). Angewandte Chemie International Edition 55(35):10210-10226. https://doi.org/10.1002/anie.201601967
Usuda M, Endo T, Nagase H, Tomono K, Ueda H (2000). Interaction of antimalarial agent artemisinin with cyclodextrins. Drug Development and Industrial Pharmacy 26(6):613-619. https://doi.org/10.1081/DDC-100101276
Vasylievna ZS, Erdemovna RT, Dorzhievna RL, Arnoldovich A-O, Long CS, Qingbo G, Qi ZF (2015). Comparative studies on composition of essential oil in three wormwoods (Artemisia L.) from Buryatia and Mongolia. Journal of Essential Oil-Bearing Plants 18(3):637-641. https://doi.org/10.1080/0972060X.2014.958547
Viljoen AM, Van Vuuren SF, Gwebu T, Demirci B, Baser KHC (2006). The geographical variation and antimicrobial activity of African wormwood (Artemisia afra Jacq.) essential oil. Journal of Essential Oil Research 18(1):19-25. https://doi.org/10.1080/10412905.2006.12067114
Wang Y, Liu J-K (2012). Improvement of the HLPC determination condition for artemisinin and its derivatives. Journal of Liquid Chromatography and Related Technologies 35(12):1712-1718. https://doi.org/10.1080/10826076.2011.621498
Wang B, Hou D, Liu Q, Wu T, Guo H, Zhang X, … Shao C (2015). Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biology and Therapy 16(10):1548-1556. https://doi.org/10.1080/15384047.2015.1071738
Wang KS, Li J, Wang Z, Mi C, Ma J, Piao LX, … Jin X (2017). Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways. Immunopharmacology and Immunotoxicology 39(1):28-36. https://doi.org/10.1080/08923973.2016.1267744
Weathers PJ, Elfawal MA, Towler MJ, Acquaah-Mensah GJ, Rich SM (2014). Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodiumchabaudi-infected mice. Journal of Ethnopharmacology 153:732-736. https://doi.org/10.1016/j.jep.2014.03.037
Wen L, LiuL, Wen L, Yu Y, Wei F (2018). Artesunate promotes G2/M cell cycle arrest in MCF7 breast cancer cells through ATM activation. Breast Cancer 25:681-686. https://doi.org/10.1007/s12282-018-0873-5
WidmerV, Handloser D, Reich E (2007). Quantitative HPTLC analysis of artemisinin in dried Artemisia annua L.: A practical approach. Journal of Liquid Chromatography and Related Technologies 30(15):2209-2219. https://doi.org/10.1080/108260707014551555
Wojtkowiak-Giera A, Derda M, Kosik-Bogacka D, Kolasa-Wolosiuk A, Solarczyk P, Cholewinski M, … Hadas E (2018). Influence of Artemisia annua L. on toll-like receptor expression in brain of mice infected with Acanthamoeba sp. Experimental Parasitology 185:17-22. https://doi.org/10.1016/j.exppara.2018.01.008
Wojtkowiak-Giera A, Derda M, Kosik-Bogacka D, Kolasa-Wolosiuk A, Wandurska-Nowak E, Jagodzinski PP, Hadas E (2019). The modulatory effect of Artemisia annua L. on toll-like receptor expression in Acanthamoeba infected mouse lungs. Experimental Parasitology 199:24-29. https://doi.org/10.1016/j.exppara.2019.02.011
Wu Y, Tang W, Zuo J (2016). Development of artemisinin drugs in the treatment of autoimmune diseases. Science Bulletin 61(1):37-41. https://doi.org/10.1007/s11434-015-0975-9
Wu Y, Jiang X, Zhang L, Zhou Y (2017). Chemical composition and biological activities of volatile oils in different periods of growth of Artemisia annua L. from China. Journal of Essential Oil-Bearing Plants 20(5):1320-1330. https://doi.org/10.1080/0972060X.2017.1392899
Xiao SH, Xue J, Mei JY, Jiao PY (2012). Effectiveness of synthetic trioxolane OZ78 against Schistosoma japonicum in mice and rabbits. Parasitology Research 110(6):2307-2314. https://doi.org/10.1007/s00436-011-2765-x
Xiao L, Tan H, Zhang L (2016). Artemisia annua glandular secretory trichomes: the bio factory of antimalarial agent artemisinin. Science Bulletin 61(1):26-36. https://doi.org/10.1007/s11434-015-0980-z
Yan L, Xiong C, Xu P, Zhu J, Yang Z, Ren H, Luo Q (2019). Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao). Carbohydrate Polymers 213:361-369. https://doi.org/10.1016/j.carbpol.2019.02.081
Yao W, Wang F, Wang H (2016). Immunomodulation of artemisinin and its derivatives. Science Bulletin 61(18):1399-1406. https://doi.org/10.1007/s11434-016-1105-z
Yao Y, Guo Q, Cao Y, Qiu Y, TanR, Yu Z, Zhou Y, Lu N (2018). Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressin TGF-β signaling in breast cancer. Journal of Experimental & Clinical Cancer Research 37:282. https://doi.org/10.1186/s13046-018-0960-7
Yuan X, Li J, LiY, Deng Z, Zhou L, Long J, Tang Y, Zuo Z, Zhang Y, Xie H (2019). Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea. Biomedicine and Pharmacotherapy 117:109181. https://doi.org/10.1016/j.biopha.2019.109181
Zeng Q-P, Zeng L-X, Lu W-J, Feng L-L, Yang R-Y, Qiu F (2012). Enhanced artemisinin production from engineered yeast precursors upon biotransformation. Biocatalysis and Biotransformation 30(2):190-202. https://doi.org/10.3109/10242422.2012.661723
Zeng H, Yuan L, Huang J (2018). Negative effects of artemisnin on phosphorus solubilizing bacteria in vitro. Ecotoxicology and Environmental Safety 158:108-113. https://doi.org/10.1016/j.ecoenv.2018.04.11
Zhang H, Zhang L, Hu X, Zhou Y, Ding C, Yang R, Wang X, Li D (2014). Optimization of ultrasound-assisted extraction of artemisinin from Artemisia annua L. by response surface methodology. Separation Science and Technology 49(5):673-681. https://doi.org/10.1080/01496395.2013.862554
Zhang H, Ji Y, Chen Q, Jiao X, Hou L, Zhu X, Zhang Z (2015). Enhancement of cytotoxicity of artemisinin toward cancer cells by transferring-mediated carbon nanotubes nanoparticles. Journal of Drug Targeting 23(6):552-567. https://doi.org/10.3109/1061186X.2015.1016437
Zhang Y, Xu G, Zhang S, Wang D, Prabha PS, Zuo Z (2018). Antitumor research on artemisinin and its bioactive derivatives. Natural Products and Bioprospecting. https://doi.org/10.1007/s13659-018-0162-1
Zhao X, Wang L, Zhang H, Zhang D, Zhang Z, Zhang J (2015). Protective effect of artemisinin on chronic alcohol induced-liver damage in mice. Environmental Toxicology and Pharmacology 52:221-226. https://doi.org/10.1016/j.etap.2017.04.008
Zhao D, Zhang J, Xu G, Wang Q (2017). Artesunate protects LPS-induced acute lung injury by inhibiting TLR4 expression and inducing Nrf2 activation. Inflammation 40:798-805. https://doi.org/10.1007/s10753-017-0524-6
Zheng W, Wang SY (2001). Antioxidant activity and phenolic compounds in selected herbs. J. Agric. Food Chemistry 49:5165-5170. https://doi.org/10.1021/jf010697n
Zhigzhitzhapova SV, Dylenova EP, Gulyaev SM, Randalova TE, Taraskin VV, Tykheev ZA, Radnaeva LD (2019). Composition and antioxidant activity of the essential oil of Artemisia annua L. Natural Product Research. http://doi.org/10.1080/14786419.2018.1548461
Zhu XX, Yang L, Li YJ, Zhang D, Chen Y, Kostecka P, Kmoniekova E, Zidek Z (2013). Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis. Pharmacological Reports 65(2):410-420. https://doi.org/10.1016/S1734-1140(13)71016-8
Zyad A, Tilaoui M, Jaafari A, Oukerrou MA, Mouse HA (2017). More insights into the pharmacological effects of artemisinin. Phytotherapy Research 1-14. https://doi.org/10.1002/ptr.5958
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